Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
Identifieur interne : 000930 ( Main/Exploration ); précédent : 000929; suivant : 000931Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
Auteurs : Shireen Nigar [Bangladesh] ; Takeshi Shimosato [Japon]Source :
- Frontiers in Nutrition [ 2296-861X ] ; 2019.
Abstract
Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9), which normally activates immune responses to pathogen-associated molecular patterns (PAMPs) indicative of infection. Oligodeoxynucleotides (ODNs) containing unmethylated CpGs mimic the immunostimulatory activity of viral/microbial DNA. Synthetic ODNs harboring CpG motifs resembling those identified in viral/microbial DNA trigger an identical response, such that these immunomodulatory ODNs have therapeutic potential. CpG DNA has been investigated as an agent for the management of malignancy, asthma, allergy, and contagious diseases, and as an adjuvant in immunotherapy. In this review, we discuss the potential synergy between synthetic ODNs and other synthetic molecules and their immunomodulatory effects. We also summarize the different synthetic molecules that function as immune modulators and outline the phenomenon of TLR-mediated immune responses. We previously reported a novel synthetic ODN that acts synergistically with other synthetic molecules (including CpG ODNs, the synthetic triacylated lipopeptide Pam3CSK4, lipopolysaccharide, and zymosan) that could serve as an immune therapy. Additionally, several clinical trials have evaluated the use of CpG ODNs with other immune factors such as granulocyte-macrophage colony-stimulating factor, cytokines, and both endosomal and cell-surface TLR ligands as adjuvants for the augmentation of vaccine activity. Furthermore, we discuss the structural recognition of ODNs by TLRs and the mechanism of functional modulation of TLRs in the context of the potential application of ODNs as wide-spectrum therapeutic agents.
Url:
DOI: 10.3389/fnut.2019.00140
PubMed: 31508424
PubMed Central: 6718720
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators</title><author><name sortKey="Nigar, Shireen" sort="Nigar, Shireen" uniqKey="Nigar S" first="Shireen" last="Nigar">Shireen Nigar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Nutrition and Food Technology, Jashore University of Science and Technology</institution>,<addr-line>Jashore</addr-line>,<country>Bangladesh</country></nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shimosato, Takeshi" sort="Shimosato, Takeshi" uniqKey="Shimosato T" first="Takeshi" last="Shimosato">Takeshi Shimosato</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University</institution>,<addr-line>Nagano</addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31508424</idno><idno type="pmc">6718720</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718720</idno><idno type="RBID">PMC:6718720</idno><idno type="doi">10.3389/fnut.2019.00140</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000979</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000979</idno><idno type="wicri:Area/Pmc/Curation">000979</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000979</idno><idno type="wicri:Area/Pmc/Checkpoint">000868</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000868</idno><idno type="wicri:Area/Ncbi/Merge">000A19</idno><idno type="wicri:Area/Ncbi/Curation">000A19</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A19</idno><idno type="wicri:Area/Main/Merge">000930</idno><idno type="wicri:Area/Main/Curation">000930</idno><idno type="wicri:Area/Main/Exploration">000930</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators</title><author><name sortKey="Nigar, Shireen" sort="Nigar, Shireen" uniqKey="Nigar S" first="Shireen" last="Nigar">Shireen Nigar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Nutrition and Food Technology, Jashore University of Science and Technology</institution>,<addr-line>Jashore</addr-line>,<country>Bangladesh</country></nlm:aff><country xml:lang="fr">Bangladesh</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shimosato, Takeshi" sort="Shimosato, Takeshi" uniqKey="Shimosato T" first="Takeshi" last="Shimosato">Takeshi Shimosato</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University</institution>,<addr-line>Nagano</addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Nutrition</title><idno type="eISSN">2296-861X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9), which normally activates immune responses to pathogen-associated molecular patterns (PAMPs) indicative of infection. Oligodeoxynucleotides (ODNs) containing unmethylated CpGs mimic the immunostimulatory activity of viral/microbial DNA. Synthetic ODNs harboring CpG motifs resembling those identified in viral/microbial DNA trigger an identical response, such that these immunomodulatory ODNs have therapeutic potential. CpG DNA has been investigated as an agent for the management of malignancy, asthma, allergy, and contagious diseases, and as an adjuvant in immunotherapy. In this review, we discuss the potential synergy between synthetic ODNs and other synthetic molecules and their immunomodulatory effects. We also summarize the different synthetic molecules that function as immune modulators and outline the phenomenon of TLR-mediated immune responses. We previously reported a novel synthetic ODN that acts synergistically with other synthetic molecules (including CpG ODNs, the synthetic triacylated lipopeptide Pam<sub>3</sub>CSK<sub>4</sub>, lipopolysaccharide, and zymosan) that could serve as an immune therapy. Additionally, several clinical trials have evaluated the use of CpG ODNs with other immune factors such as granulocyte-macrophage colony-stimulating factor, cytokines, and both endosomal and cell-surface TLR ligands as adjuvants for the augmentation of vaccine activity. 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uniqKey="Takechi Y">Y Takechi</name></author><author><name sortKey="Houghton, An" uniqKey="Houghton A">AN Houghton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klebanoff, Ca" uniqKey="Klebanoff C">CA Klebanoff</name></author><author><name sortKey="Gattinoni, L" uniqKey="Gattinoni L">L Gattinoni</name></author><author><name sortKey="Restifo, Np" uniqKey="Restifo N">NP Restifo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohno, S" uniqKey="Ohno S">S Ohno</name></author><author><name sortKey="Okuyama, R" uniqKey="Okuyama R">R Okuyama</name></author><author><name sortKey="Aruga, A" uniqKey="Aruga A">A Aruga</name></author><author><name sortKey="Sugiyama, H" uniqKey="Sugiyama H">H Sugiyama</name></author><author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M Yamamoto</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Bangladesh</li><li>Japon</li></country></list><tree><country name="Bangladesh"><noRegion><name sortKey="Nigar, Shireen" sort="Nigar, Shireen" uniqKey="Nigar S" first="Shireen" last="Nigar">Shireen Nigar</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Shimosato, Takeshi" sort="Shimosato, Takeshi" uniqKey="Shimosato T" first="Takeshi" last="Shimosato">Takeshi Shimosato</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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